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Cortisol, a [[ | Cortisol, a [[Steroid hormone|steroid hormone]], is the main [[Glucocorticoids|glucocorticoid]] secreted by the ''zona fasciculata'' of the [[Adrenal cortex|adrenal cortex]] <ref>Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p759</ref>. It's primary function is to increase blood sugar levels. This rise is achieved through various processes including [https://teaching.ncl.ac.uk/bms/wiki/index.php/Gluconeogenesis gluconeogenesis] and [https://teaching.ncl.ac.uk/bms/wiki/index.php/Metabolism metabolism] of several macromolecules including [https://teaching.ncl.ac.uk/bms/wiki/index.php/Fat fat], [https://teaching.ncl.ac.uk/bms/wiki/index.php/Protein protein] and [https://teaching.ncl.ac.uk/bms/wiki/index.php/Carbohydrate carbohydrate].<br>In a response to stress, the glucocorticoid is released from the zona fasciculata domain of the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Adrenal_cortex adrenal cortex]. This release is ultimately controlled by the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Hypothalamus hypothalamus] in the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Brain brain], which secretes [https://teaching.ncl.ac.uk/bms/wiki/index.php?title=Corticotropin-releasing_hormone&action=edit&redlink=1 corticotropin-releasing hormone (CRH)]. This hormone then triggers the secretion of another hormone, [https://teaching.ncl.ac.uk/bms/wiki/index.php/ACTH ACTH], from the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Pituitary_gland pituitary gland] which is carried, via the bloodstream, to the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Adrenal_cortex adrenal cortex]. | ||
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=== References === | === References === | ||
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Revision as of 23:59, 15 November 2016
Cortisol, a steroid hormone, is the main glucocorticoid secreted by the zona fasciculata of the adrenal cortex [1]. It's primary function is to increase blood sugar levels. This rise is achieved through various processes including gluconeogenesis and metabolism of several macromolecules including fat, protein and carbohydrate.
In a response to stress, the glucocorticoid is released from the zona fasciculata domain of the adrenal cortex. This release is ultimately controlled by the hypothalamus in the brain, which secretes corticotropin-releasing hormone (CRH). This hormone then triggers the secretion of another hormone, ACTH, from the pituitary gland which is carried, via the bloodstream, to the adrenal cortex.
References
- ↑ Silverthorn, Dee Unglaub., Johnson, Bruce R., Ober, William C., Garrison, Claire W., Silverthorn, Andrew C.(2009)Human Physiology: An integrated approach, 5th edition, New York: Pearson International. p759