Depolarisation: Difference between revisions
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When something is polarised its ends are oppositely charged. So, depolarisation is when the difference is balanced, the ends no longer have different [[Charges|charges]]. | When something is polarised its ends are oppositely charged. So, depolarisation is when the difference is balanced, the ends no longer have different [[Charges|charges]]. | ||
For example in [[Neural stimulation|neural stimulation]], a neurone can become depolarised when the [[Cells|cells]] [[ | For example in [[Neural stimulation|neural stimulation]], a neurone can become depolarised when the [[Cells|cells]] [[Resting membrane potential|resting membrane potential]] (RMP) (-75 mV) becomes more positive (+40 mV). This occurs when the cell is stimulated via an [[Action potential|action potential]]; the [[Membrane potential|membrane]] contains [[Voltage-gated sodium channel|voltage-gated sodium channels]] that become more permeable to [[Sodium ions|sodium ions]] allowing them to diffuse out of the cell down their concentration gradient, making the overall charge more negative relative to the outside. | ||
When a membrane becomes depolarised this can trigger an [[Action potential|action potential]]. This can be defined as a rise in the [[Membrane potential|membrane potential]] to +55mv which is considered the [[Threshold potential|threshold voltage]]. This threshold voltage is triggered when a stimulus is large enough to generate a high frequency of action potentials. When the membrane potential then falls back to the RMP this is reffered to as repolarisation. Typically, repolarisation results in [[Hyperpolarisation|hyperpolarisation]] of the membrane (a potential lower than the RMP) as [[Voltage gated potassium channels|potassium channels]] take a longer time to close than [[Voltage gated sodium channels|sodium channels]]. | |||
When a membrane becomes depolarised this can trigger an [[ | |||
Revision as of 08:57, 26 November 2016
When something is polarised its ends are oppositely charged. So, depolarisation is when the difference is balanced, the ends no longer have different charges.
For example in neural stimulation, a neurone can become depolarised when the cells resting membrane potential (RMP) (-75 mV) becomes more positive (+40 mV). This occurs when the cell is stimulated via an action potential; the membrane contains voltage-gated sodium channels that become more permeable to sodium ions allowing them to diffuse out of the cell down their concentration gradient, making the overall charge more negative relative to the outside.
When a membrane becomes depolarised this can trigger an action potential. This can be defined as a rise in the membrane potential to +55mv which is considered the threshold voltage. This threshold voltage is triggered when a stimulus is large enough to generate a high frequency of action potentials. When the membrane potential then falls back to the RMP this is reffered to as repolarisation. Typically, repolarisation results in hyperpolarisation of the membrane (a potential lower than the RMP) as potassium channels take a longer time to close than sodium channels.