Penetrance: Difference between revisions
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Penetrance is the percentage of the expression of the [[Phenotype|phenotype]] in an [[Organism|organism]] from its adjacent [[Genotype|genotype]] <ref>Hartl, D.L., Ruvolo, M. (2012) Genetics:Analysis Of Genes And Genomes, United States of America: Jones and Bartlett</ref> (e.g. how many members of a [[Population|population]] with a specific genotype that show the expected phenotype). | Penetrance is the percentage of the expression of the [[Phenotype|phenotype]] in an [[Organism|organism]] from its adjacent [[Genotype|genotype]] <ref>Hartl, D.L., Ruvolo, M. (2012) Genetics:Analysis Of Genes And Genomes, United States of America: Jones and Bartlett</ref> (e.g. how many members of a [[Population|population]] with a specific genotype that show the expected phenotype). | ||
An example of complete pentrance is neurofibromatosis type I. The symptoms of this mutation will be shown in all of the mutants - 100% penetrance. <ref>NHS. (ND). Penetrance. Available at: http://www.geneticseducation.nhs.uk/genetic-glossary/221-penetrance (Accessed at: 26/11/14)</ref> | An example of complete pentrance is [[neurofibromatosis type 1|neurofibromatosis type I]]. The symptoms of this mutation will be shown in all of the mutants - 100% penetrance. <ref>NHS. (ND). Penetrance. Available at: http://www.geneticseducation.nhs.uk/genetic-glossary/221-penetrance (Accessed at: 26/11/14)</ref> | ||
Incomplete penetrance is when some individuals with a particular (dominant) mutation express a wild type phenotype.An example is polydactyly. | Incomplete penetrance is when some individuals with a particular (dominant) mutation express a wild type phenotype.An example is [[Polydactyly|polydactyly]]. | ||
=== Reference === | === Reference === | ||
<references /> | <references /> | ||
Revision as of 17:40, 26 November 2016
Penetrance is the percentage of the expression of the phenotype in an organism from its adjacent genotype [1] (e.g. how many members of a population with a specific genotype that show the expected phenotype).
An example of complete pentrance is neurofibromatosis type I. The symptoms of this mutation will be shown in all of the mutants - 100% penetrance. [2]
Incomplete penetrance is when some individuals with a particular (dominant) mutation express a wild type phenotype.An example is polydactyly.
Reference
- ↑ Hartl, D.L., Ruvolo, M. (2012) Genetics:Analysis Of Genes And Genomes, United States of America: Jones and Bartlett
- ↑ NHS. (ND). Penetrance. Available at: http://www.geneticseducation.nhs.uk/genetic-glossary/221-penetrance (Accessed at: 26/11/14)