Fructose-6-phosphate: Difference between revisions
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Fructose-6-phosphate is one of the metabolites of the[[ | Fructose-6-phosphate is one of the metabolites of the [[Carbohydrates metabolism|carbohydrates metabolism]] pathway, which has [[Glucose-6-phosphate|glucose-6-phosphate]] as a precursor and [[Fructose-1,6-bisphosphate|fructose-1,6-biphosphate]] as a postcursor . More specifically, it is found in the [[Glycolysis|glycolysis]] stage of the carbohydrates metabolism. | ||
= Production of fructose-6-phosphate from glucose-6-phosphate = | = Production of fructose-6-phosphate from glucose-6-phosphate = | ||
Fructose-6-phosphate results from a [[ | Fructose-6-phosphate results from a [[Aldopyranose|aldopyranose]] to [[Ketofuranose|ketofuranose]] conversion which involves a sequence of events. These events are catalysed by [[Phosphoglucose isomerase|phosphoglucose isomerase]]. The first one is a conversion from the ring form of glucose-6-phosphate to the linear form. The second one is the conversion from this linear form to a linear ketohexose form by a nucelophilic attack of the double bonded oxygen atom on the first carbon atom. Then, the linear ketohexose is converted to its ring form by carbon 2 binding covalently to the oxygen atom on carbon 5.<br> | ||
= Conversion of fructose-6-phosphate to fructose-1,6-biphosphate = | = Conversion of fructose-6-phosphate to fructose-1,6-biphosphate = | ||
This conversion involves an enzyme called [[ | This conversion involves an enzyme called [[Phosphofructokinase|phosphofructokinase]]. It phosphorylates carbon 1 of fructose-6-phosphate by adding a phosphate group from ATP. The process involves the ATP forming a complex with Mg<sup>2+ </sup>in which the ion neutralises the charges of the alpha and beta [[Phosphoryl group|phosphoryl groups]] of ATP .This way, only the gamma phosphoryl group of ATP is used for phosphorylation.<span style="font-size: 11.0667px;" /> | ||
= Importance of conversion between glucose-6-phosphate and fructose-1,6-biphosphate = | = Importance of conversion between glucose-6-phosphate and fructose-1,6-biphosphate = | ||
Revision as of 17:00, 1 December 2016
Fructose-6-phosphate is one of the metabolites of the carbohydrates metabolism pathway, which has glucose-6-phosphate as a precursor and fructose-1,6-biphosphate as a postcursor . More specifically, it is found in the glycolysis stage of the carbohydrates metabolism.
Production of fructose-6-phosphate from glucose-6-phosphate
Fructose-6-phosphate results from a aldopyranose to ketofuranose conversion which involves a sequence of events. These events are catalysed by phosphoglucose isomerase. The first one is a conversion from the ring form of glucose-6-phosphate to the linear form. The second one is the conversion from this linear form to a linear ketohexose form by a nucelophilic attack of the double bonded oxygen atom on the first carbon atom. Then, the linear ketohexose is converted to its ring form by carbon 2 binding covalently to the oxygen atom on carbon 5.
Conversion of fructose-6-phosphate to fructose-1,6-biphosphate
This conversion involves an enzyme called phosphofructokinase. It phosphorylates carbon 1 of fructose-6-phosphate by adding a phosphate group from ATP. The process involves the ATP forming a complex with Mg2+ in which the ion neutralises the charges of the alpha and beta phosphoryl groups of ATP .This way, only the gamma phosphoryl group of ATP is used for phosphorylation.<span style="font-size: 11.0667px;" />