Rho independent terminators: Difference between revisions
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Rho- independent termination ( also known as intrinsic termination) is a process carried out in prokaryotic organisms as a mechanism for stopping [[Transcription]]. | Rho-independent termination (also known as intrinsic termination) is a process carried out in [[Prokaryotic|prokaryotic]] [[Organisms|organisms]] as a mechanism for stopping [[Transcription|transcription]]. The [[MRNA|mRNA]] [[Molecules|molecule]] has a sequence of base pairs with a high proportion of [[Cytosine|cytosine]] and [[Guanine|guanine]] bases, these are able to strongly bond to one another with 3 [[Hydrogen bond|hydrogen bonds]] forming a [[RNA duplex|RNA duplex]] in a [[Stable hairpin structure|stable hairpin structure]]<ref>Lewin, Benjamin (2007). Genes IX. Sudbury, MA: Jones and Bartlett Publishers. ISBN 0-7637-4063-2.</ref> succeeding the hairpin structure is a chain of [[Uracil|uracil]] bases, which only form weak bonds with [[Adenine|adenine]]. The transcription of the uracil sequence is coupled with a [[Protein|protein]], located on the [[RNA polymerase]], binding to the hairpin structure causing the [[RNA polymerase|RNA polymerase]] to temporarily stop<ref>Wilson KS, von Hippel PH (September 1995). "Transcription termination at intrinsic terminators: the role of the RNA hairpin". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8793–7.</ref>. The temporary lapse and weak uracil-adenine bonds cause the hairpin structure to unwind and dissociate from the RNA polymerase, thus terminating [[Transcription|transcription]]. | ||
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Latest revision as of 16:56, 4 December 2016
Rho-independent termination (also known as intrinsic termination) is a process carried out in prokaryotic organisms as a mechanism for stopping transcription. The mRNA molecule has a sequence of base pairs with a high proportion of cytosine and guanine bases, these are able to strongly bond to one another with 3 hydrogen bonds forming a RNA duplex in a stable hairpin structure[1] succeeding the hairpin structure is a chain of uracil bases, which only form weak bonds with adenine. The transcription of the uracil sequence is coupled with a protein, located on the RNA polymerase, binding to the hairpin structure causing the RNA polymerase to temporarily stop[2]. The temporary lapse and weak uracil-adenine bonds cause the hairpin structure to unwind and dissociate from the RNA polymerase, thus terminating transcription.