CORN law: Difference between revisions
Created page with "The CORN law is the rule that allows to distinquish [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enantiomer enantiomers] from each other. In other word, it determines whether t..." |
No edit summary |
||
| Line 1: | Line 1: | ||
The CORN law is the rule that allows to distinquish [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enantiomer enantiomers] from each other. In other | The CORN law is the rule that allows to distinquish [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enantiomer enantiomers] from each other. In other words, it determines whether the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Amino_acids amino acid] is a [https://teaching.ncl.ac.uk/bms/wiki/index.php/Optical_isomers L-isomer or D-isomer]. All amino acids have the same core and differ due to their side chain. There are four different groups attached to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Alpha_carbon α-carbon], making α-amino acids [https://teaching.ncl.ac.uk/bms/wiki/index.php/Chiral_centre chiral]. These groups are: [https://teaching.ncl.ac.uk/bms/wiki/index.php/Carboxyl_group carboxylic acid group ](-COO<sup>-</sup>), [https://teaching.ncl.ac.uk/bms/wiki/index.php/Amino_group amino group] (-NH<sub>2</sub>), a [https://teaching.ncl.ac.uk/bms/wiki/index.php/Hydrogen hydrogen] atom and a distinctive R group (representation of side chain).<br> | ||
The '''CORN''' is an acronym for -'''CO'''OH , the -'''R''' and -'''N'''H<sub>2</sub> groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer<sup>[1]</sup>. | The '''CORN''' is an acronym for -'''CO'''OH , the -'''R''' and -'''N'''H<sub>2</sub> groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer<sup>[1]</sup>. | ||
Revision as of 02:42, 5 December 2016
The CORN law is the rule that allows to distinquish enantiomers from each other. In other words, it determines whether the amino acid is a L-isomer or D-isomer. All amino acids have the same core and differ due to their side chain. There are four different groups attached to α-carbon, making α-amino acids chiral. These groups are: carboxylic acid group (-COO-), amino group (-NH2), a hydrogen atom and a distinctive R group (representation of side chain).
The CORN is an acronym for -COOH , the -R and -NH2 groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer[1].
References:
1.Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Biochemsitry. 7th. ed. New York: WH Freeman and Company. 2011.