Cylin dependent kinases: Difference between revisions
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Cyclin Dependent Kinases (Cdk) are [[Enzyme|enzymes]] assocaited with different checkpoints within the [[Eukaryotic|eukaryotic]] [[Cell cycle|cell cycle]]. They belong to the family of enzymes; [[Kinases|kinases]], and work by [[Phosphorylation|phosphorylating]] [[Proteins|proteins]] thus, activating or deactivating other protiens or pathways within the [[Cell|cell]]. Cyclin dependent kinases as the name suggests are dependent on a protein called [[Cyclin|cyclin]], which at differing periods within the cell cycle is readily available to bind to Cdk's. This high affinity binding of the Cdk and the cyclin protein activates the enzyme activity within the kinase. The Cdk's occur at checkpoints within the cell cycle as I mentioned earlier, these checkpoints occur at the end of the [[The cell cycle|G<sub>1 </sub>phase throughout]] the [[The cell cycle|S phase]] and on entry to the [[The cell cycle|M phase]].<ref name="null">Alberts, B, et al, 2007, pg 1062. Molecular Biology of THE CELL. Fifth Edition. New York: NY. Garland Science, Taylor &amp;amp;amp; Francis Group.</ref> These checkpoints act as a window of choice within the cell cycle where by the cell can either continue on to the next stage, enter a stage of quiesence called [[The cell cycle|G<sub>0</sub>]] or induce the nessecary mechanisms for programmed cell death, or [[Apoptosis|apoptosis]]. | Cyclin Dependent Kinases (Cdk) are [[Enzyme|enzymes]] assocaited with different checkpoints within the [[Eukaryotic|eukaryotic]] [[Cell cycle|cell cycle]]. They belong to the family of enzymes; [[Kinases|kinases]], and work by [[Phosphorylation|phosphorylating]] [[Proteins|proteins]] thus, activating or deactivating other protiens or pathways within the [[Cell|cell]]. Cyclin dependent kinases as the name suggests are dependent on a protein called [[Cyclin|cyclin]], which at differing periods within the cell cycle is readily available to bind to Cdk's. This high affinity binding of the Cdk and the cyclin protein activates the enzyme activity within the kinase. The Cdk's occur at checkpoints within the cell cycle as I mentioned earlier, these checkpoints occur at the end of the [[The cell cycle|G<sub>1 </sub>phase throughout]] the [[The cell cycle|S phase]] and on entry to the [[The cell cycle|M phase]].<ref name="null">Alberts, B, et al, 2007, pg 1062. Molecular Biology of THE CELL. Fifth Edition. New York: NY. Garland Science, Taylor &amp;amp;amp;amp;amp; Francis Group.</ref> These checkpoints act as a window of choice within the cell cycle where by the cell can either continue on to the next stage, enter a stage of quiesence called [[The cell cycle|G<sub>0</sub>]] or induce the nessecary mechanisms for programmed cell death, or [[Apoptosis|apoptosis]]. | ||
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Revision as of 17:40, 26 November 2010
Cyclin Dependent Kinases (Cdk) are enzymes assocaited with different checkpoints within the eukaryotic cell cycle. They belong to the family of enzymes; kinases, and work by phosphorylating proteins thus, activating or deactivating other protiens or pathways within the cell. Cyclin dependent kinases as the name suggests are dependent on a protein called cyclin, which at differing periods within the cell cycle is readily available to bind to Cdk's. This high affinity binding of the Cdk and the cyclin protein activates the enzyme activity within the kinase. The Cdk's occur at checkpoints within the cell cycle as I mentioned earlier, these checkpoints occur at the end of the G1 phase throughout the S phase and on entry to the M phase.[1] These checkpoints act as a window of choice within the cell cycle where by the cell can either continue on to the next stage, enter a stage of quiesence called G0 or induce the nessecary mechanisms for programmed cell death, or apoptosis.
References
- ↑ Alberts, B, et al, 2007, pg 1062. Molecular Biology of THE CELL. Fifth Edition. New York: NY. Garland Science, Taylor &amp;amp;amp;amp; Francis Group.