Mediator: Difference between revisions
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Mediator itself is a large complex consisting of approximately 22 polypeptides. This large structure is formed from 3 domains: the head, middle and tail which as unit can either exist on its own or associated with RNA polymerase II via the c-terminal domain. | Mediator itself is a large complex consisting of approximately 22 [[polypeptides|polypeptides]]. This large structure is formed from 3 domains: the head, middle and tail which as unit can either exist on its own or associated with [[RNA polymerase II|RNA polymerase II]] via the c-terminal domain. | ||
=== | === Function === | ||
The main function of the mediator complex is to interact with activators. These mediator-activator interactions, along with other transcription factors, aid the recruitment and assembly of the pre-initiation complex (PIC)<ref>Poss Z., Ebmeier C., Taatjes D. (2013) Critical Views in Biochemistry and Molecular Biology, Volume 38, Page 575-608.</ref>. | The main function of the mediator complex is to interact with activators. These mediator-activator interactions, along with other transcription factors, aid the recruitment and assembly of the pre-initiation complex (PIC)<ref>Poss Z., Ebmeier C., Taatjes D. (2013) Critical Views in Biochemistry and Molecular Biology, Volume 38, Page 575-608.</ref>. | ||
=== Reference === | === Reference === | ||
<references /> | <references /> | ||
Revision as of 18:52, 23 October 2017
Mediator itself is a large complex consisting of approximately 22 polypeptides. This large structure is formed from 3 domains: the head, middle and tail which as unit can either exist on its own or associated with RNA polymerase II via the c-terminal domain.
Function
The main function of the mediator complex is to interact with activators. These mediator-activator interactions, along with other transcription factors, aid the recruitment and assembly of the pre-initiation complex (PIC)[1].
Reference
- ↑ Poss Z., Ebmeier C., Taatjes D. (2013) Critical Views in Biochemistry and Molecular Biology, Volume 38, Page 575-608.