T cell receptor: Difference between revisions
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The T cell receptors are found on [[T-cells|T cells ]](T lymphocytes). | The T cell receptors are found on [[T-cells|T cells ]](T lymphocytes). T cells are involved in the cell mediated response. T cell receptors are dimers. Most commonly T cell receptors consist of two glycosylated disulphide-linked alpha and beta chains. A very small amount is made of a gamma and delta units. The chains are associated with CD3 proteins to make T cell receptors CD3 at the cell surface membrane. Gamma and alpha chains are also associated with CD3 proteins. T cells are able to distinguish antigens which have been processed into surface peptides and bound to MHCs<ref>Marie-Paule Lefranc, Gérard Lefranc. The T Cell Receptor FactsBook. Academic press: 2001 p14-24</ref>. <br> | ||
T helper cells recognise peptide antigens which are bound to MHC class II molecules on dendrite cells, macrophages and B cells. There are 2 types of T helper cells; Th1 cells destroy virus infected cells and stimulate B-cell activation and Th2 which assist B-cells to develop into memory cells and plasma cells which manufacture antibodies<ref>Lydyard, P., Whelan, A., & Fanger, M. (2011). Immunology (3rd ed., Instant notes series). New York ; London: Taylor & Francis.</ref>. <br> | |||
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Revision as of 17:49, 30 November 2017
The T cell receptors are found on T cells (T lymphocytes). T cells are involved in the cell mediated response. T cell receptors are dimers. Most commonly T cell receptors consist of two glycosylated disulphide-linked alpha and beta chains. A very small amount is made of a gamma and delta units. The chains are associated with CD3 proteins to make T cell receptors CD3 at the cell surface membrane. Gamma and alpha chains are also associated with CD3 proteins. T cells are able to distinguish antigens which have been processed into surface peptides and bound to MHCs[1].
T helper cells recognise peptide antigens which are bound to MHC class II molecules on dendrite cells, macrophages and B cells. There are 2 types of T helper cells; Th1 cells destroy virus infected cells and stimulate B-cell activation and Th2 which assist B-cells to develop into memory cells and plasma cells which manufacture antibodies[2].
References