DNA polymerase I: Difference between revisions

Revision as of 22:15, 27 November 2010

DNA polymerase I is an enzyme that is involved in DNA replication in E'.coli

1) 5’→3’ exonuclease activity to remove RNA primers ahead of the polymerase site^[1].
2) 3’→5’ exonuclease activity for proof-reading and accuracy.

↑ Berg J, Tymoczko J, Stryer L (2007) Biochemistry, 6th edition, New York: W.H. Freeman, p. 801

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	DNA polymerase I is an enzyme that is involved in DNA replication in [[E.Coli\|''E''''.coli'']]. It is part of a group of [[DNA polymerase\|DNA polymerases that]] copy DNA; they are highly coordinated in order to replicate whole genomes precisely and rapidly. DNA polymerase I is a slow, non-processive enzyme that fills the gaps between [[Okazaki fragment\|Okazaki fragments of]] the lagging strand by Watson-Crick base pairing. The enzyme has two additional activites:		DNA polymerase I is an enzyme that is involved in DNA replication in [[E.Coli\|''E''''.coli''''']]

	1) 5’→3’ exonuclease activity to remove RNA primers ahead of the polymerase site<ref>Berg J, Tymoczko J, Stryer L (2007) Biochemistry, 6th edition, New York: W.H. Freeman, p. 801</ref>.<br>2) 3’→5’ exonuclease activity for proof-reading and accuracy.		1) 5’→3’ exonuclease activity to remove RNA primers ahead of the polymerase site<ref>Berg J, Tymoczko J, Stryer L (2007) Biochemistry, 6th edition, New York: W.H. Freeman, p. 801</ref>.<br>2) 3’→5’ exonuclease activity for proof-reading and accuracy.