X-linked recessive disorder: Difference between revisions
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A short explanation of inheritance of recessive X-linked genes and an example of a disorder |
Added the references correctly, that is, I added them as explained in the lecture. Cleaned up the text. Removed some stray code. |
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Some recessive genes are located on the X chromosome and are therefore inherited differently in males and females. For a male, who has one X chromosome, the recessive phenotype is always expressed. For a female, however, the phenotype is only expressed if she is homozygous for the recessive allele. If she is heterozygous, she is simply a carrier of the allele. In 1910, Thomas Hunt Morgan showed in flies that the white-eye mutation was X-linked thanks to crosses and reciprocal crosses<ref name="dl">Daniel L. Hartl and Maryellen Ruvolo, Genetics: Analysis of Genes and Genomes, Eighth edition, USA, Jones and Bartlett Learning, 2012</ref>. | |||
Many diseases follow the same inheritance pattern. These are known as X-linked recessive disorders. An example is the genetic transmission of haemophilia A in the British royal family<ref name="dl">Daniel L. Hartl and Maryellen Ruvolo, Genetics: Analysis of Genes and Genomes, Eighth edition, USA, Jones and Bartlett Learning, 2012</ref>. | |||
=== References === | |||
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Revision as of 13:20, 1 December 2017
Some recessive genes are located on the X chromosome and are therefore inherited differently in males and females. For a male, who has one X chromosome, the recessive phenotype is always expressed. For a female, however, the phenotype is only expressed if she is homozygous for the recessive allele. If she is heterozygous, she is simply a carrier of the allele. In 1910, Thomas Hunt Morgan showed in flies that the white-eye mutation was X-linked thanks to crosses and reciprocal crosses[1].
Many diseases follow the same inheritance pattern. These are known as X-linked recessive disorders. An example is the genetic transmission of haemophilia A in the British royal family[1].