Summation: Difference between revisions
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There are two types of summation: spatial summation and temporal summation that occur between [[Neuron|neurones]]. | There are two types of summation: spatial summation and temporal summation that occur between [[Neuron|neurones]]. | ||
=== Spatial summation<ref>Alberts B. et al, Molecular Biology of the Cell 3rd edition, p541-542</ref> === | === Spatial summation<ref>Alberts B. et al, Molecular Biology of the Cell 3rd edition, p541-542</ref> === | ||
Spatial summation | Spatial summation is the effect of triggering an action potential in a neuron from one or more presynaptic neurons<ref>Levin and Luders (2000). Comprehensive Clinical Neurophysiology. New York: W.B. Saunders Company.</ref>. This occurs when more than one [[Excitatory postsynaptic potential|excitatory postsynaptic potential]] (EPSP) originates simultaneously and a different part on the [[Neuron|neurone]]. If all of the EPSPs are subthreshold then an [[Action potential|action potential]] will not be fired once they reach the [[Neuron|neurone]] individually. However, if they all stimulate the neurone simultaneously at the trigger zone, then the subthreshold EPSP’s will sum up to create a suprathreshold that exceed the threshold voltage which will then generate an action potential. | ||
Another form of spatial summation is that which involve an [[Inhibitory postsynaptic potential|inhibitory postsynaptic potential]] (IPSP) which reaches the neurone at the same time as the multiple EPSPs and the sum of the IPSP and EPSP’s (the summed potential) is subthreshold so no action potential is generated as the IPSP has diminished the EPSPs. Spatial summation in this example is known as [[Postsynaptic inhibition|postsynaptic inhibition]]. | Another form of spatial summation is that which involve an [[Inhibitory postsynaptic potential|inhibitory postsynaptic potential]] (IPSP) which reaches the neurone at the same time as the multiple EPSPs and the sum of the IPSP and EPSP’s (the summed potential) is subthreshold so no action potential is generated as the IPSP has diminished the EPSPs. Spatial summation in this example is known as [[Postsynaptic inhibition|postsynaptic inhibition]]. | ||
=== Temporal summation<ref>Alberts B. et al, Molecular Biology of the Cell 3rd edition, p541-542</ref> === | === Temporal summation<ref>Alberts B. et al, Molecular Biology of the Cell 3rd edition, p541-542</ref> === | ||
This happens when the summation of graded potentials originates from one [[Presynaptic neurone|presynaptic neurone]] or in other words, the signals | This happens when the summation of graded potentials originates from one [[Presynaptic neurone|presynaptic neurone]] or in other words, the signals overlap reaching a postsynaptic neurone. If a subthreshold EPSP reaches the neurone then no action potential will be generated, however, if multiple subthreshold EPSPs reach the neurone trigger zone close enough together in time then the two subthreshold EPSPs will sum up to cause a suprathreshold EPSP and an action potential will be generated. This is an example of [[Postsynaptic integration|postsynaptic integration]]. | ||
=== References | === References === | ||
<references /> | <references /> | ||
Revision as of 17:56, 4 December 2017
There are two types of summation: spatial summation and temporal summation that occur between neurones.
Spatial summation[1]
Spatial summation is the effect of triggering an action potential in a neuron from one or more presynaptic neurons[2]. This occurs when more than one excitatory postsynaptic potential (EPSP) originates simultaneously and a different part on the neurone. If all of the EPSPs are subthreshold then an action potential will not be fired once they reach the neurone individually. However, if they all stimulate the neurone simultaneously at the trigger zone, then the subthreshold EPSP’s will sum up to create a suprathreshold that exceed the threshold voltage which will then generate an action potential.
Another form of spatial summation is that which involve an inhibitory postsynaptic potential (IPSP) which reaches the neurone at the same time as the multiple EPSPs and the sum of the IPSP and EPSP’s (the summed potential) is subthreshold so no action potential is generated as the IPSP has diminished the EPSPs. Spatial summation in this example is known as postsynaptic inhibition.
Temporal summation[3]
This happens when the summation of graded potentials originates from one presynaptic neurone or in other words, the signals overlap reaching a postsynaptic neurone. If a subthreshold EPSP reaches the neurone then no action potential will be generated, however, if multiple subthreshold EPSPs reach the neurone trigger zone close enough together in time then the two subthreshold EPSPs will sum up to cause a suprathreshold EPSP and an action potential will be generated. This is an example of postsynaptic integration.