Antigen presenting cells: Difference between revisions
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Antigen Presenting Cells (or APCs) are involved in the [[Immune system|immune system]] and activation of [[T cells|T-cells]]. APCs cover several cell types including [[Dendritic cell|dendritic cells]] | Antigen Presenting Cells (or APCs) are involved in the [[Immune system|immune system]] and activation of [[T cells|T-cells]]. APCs cover several cell types including [[Dendritic cell|dendritic cells]], [[Macrophage|macrophages]] and B cells. They express MHC II molecules which bind small peptides from a pathogen to present it to T cells. <br> | ||
== Dendritic cells == | == Dendritic cells == | ||
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== Macrophages == | == Macrophages == | ||
[[Macrophage|Macrophages]] perform [[Phagocytosis|phagocytosis]] upon any invading molecule/cell that it recognises, the digested material are then presented on its cell surface to [[Activate T-cells|activate T-cells]] to destroy any more of the invader is present. [[Macrophage|Macrophages]] are mature cells that reside in most tissues, some tissues have specialised versions of [[Macrophage|macrophages]], and in the limphoid organs <ref>Murphy K, et al.;Janeway's Immunobiology; 7th ed; 2008</ref>. | [[Macrophage|Macrophages]] perform [[Phagocytosis|phagocytosis]] upon any invading molecule/cell that it recognises, the digested material are then presented on its cell surface to [[Activate T-cells|activate T-cells]] to destroy any more of the invader is present. [[Macrophage|Macrophages]] are mature cells that reside in most tissues, some tissues have specialised versions of [[Macrophage|macrophages]], and in the limphoid organs <ref>Murphy K, et al.;Janeway's Immunobiology; 7th ed; 2008</ref>. | ||
== References == | == References == | ||
<references /> | <references /> |
Revision as of 15:53, 22 October 2018
Antigen Presenting Cells (or APCs) are involved in the immune system and activation of T-cells. APCs cover several cell types including dendritic cells, macrophages and B cells. They express MHC II molecules which bind small peptides from a pathogen to present it to T cells.
Dendritic cells
Dendritic cells have long projections away from the main cell body similar to the dendrites found on the nerve cell (hence the name). Thes cells begin as all cells in the immune system do, they are created by differentiation of pluripotent stem cells found in the bone marrow. Immature dendritic cells leave the bone marrow traveling in the blood stream into tissues, as they travel they perform macropinocytosis to take in large amounts of ECF. Dendritic cells do have the ability to digest pathogens they encounter but their main function in the immune system is to activate virgin T-cells by presenting any foriegen molecules that has been picked up on the cell's travels. This gives a vital link between the innate and adaptive immune response.
Macrophages
Macrophages perform phagocytosis upon any invading molecule/cell that it recognises, the digested material are then presented on its cell surface to activate T-cells to destroy any more of the invader is present. Macrophages are mature cells that reside in most tissues, some tissues have specialised versions of macrophages, and in the limphoid organs [1].
References
- ↑ Murphy K, et al.;Janeway's Immunobiology; 7th ed; 2008