Prions: Difference between revisions
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Not all infectious diseases are transmitted by bacteria or [[Virus|viruses]]. Some neurological diseases, such as [[Creutzfeldt-Jaakob disease (CJD)|Creutzfeldt-Jaakob disease (CJD)]] or mad cow disease are in fact caused by agents called '''Prions, '''which are of similar size to viruses but are made up of only [[Protein|protein]] <ref | Not all infectious diseases are transmitted by bacteria or [[Virus|viruses]]. Some neurological diseases, such as [[Creutzfeldt-Jaakob disease (CJD)|Creutzfeldt-Jaakob disease (CJD)]] or mad cow disease are in fact caused by agents called '''Prions, '''which are of similar size to viruses but are made up of only [[Protein|protein]] <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref> | ||
'''Prions '''have these characteristics: | '''Prions '''have these characteristics: | ||
1.) "The transmissible agent consists of aggregated forms of a specific protein" <ref>J. M. Berg et. | 1.) "The transmissible agent consists of aggregated forms of a specific protein" <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>. | ||
2.) These protein aggregates cannot be degraded by the agents that degrade most other proteins <ref>J. M. Berg et. | 2.) These [[Protein|protein]] aggregates cannot be degraded by the agents that degrade most other proteins <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>. | ||
3.) "The protein is largely or completely derived from a cellular protein called PrP, that is normally present in the brain" <ref>J. M. Berg et. | 3.) "The protein is largely or completely derived from a cellular protein called PrP, that is normally present in the brain" <ref>J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>. | ||
So an aggregated form of a protein (that is already present in the brain) is the infectious agent in prion diseases <ref | So an aggregated form of a protein (that is already present in the brain) is the infectious agent in prion diseases <ref>J. M. Berg et al. (2007) p 54, Biochemistry, Sixth edition, New York, W.H. Freeman and Company</ref>.<br> | ||
=== References === | === References === | ||
<references /> | |||
Revision as of 15:50, 9 January 2011
Not all infectious diseases are transmitted by bacteria or viruses. Some neurological diseases, such as Creutzfeldt-Jaakob disease (CJD) or mad cow disease are in fact caused by agents called Prions, which are of similar size to viruses but are made up of only protein [1]
Prions have these characteristics:
1.) "The transmissible agent consists of aggregated forms of a specific protein" [2].
2.) These protein aggregates cannot be degraded by the agents that degrade most other proteins [3].
3.) "The protein is largely or completely derived from a cellular protein called PrP, that is normally present in the brain" [4].
So an aggregated form of a protein (that is already present in the brain) is the infectious agent in prion diseases [5].
References
- ↑ J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
- ↑ J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
- ↑ J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
- ↑ J. M. Berg et al. (2007) p 53, Biochemistry, Sixth edition, New York, W.H. Freeman and Company
- ↑ J. M. Berg et al. (2007) p 54, Biochemistry, Sixth edition, New York, W.H. Freeman and Company