Gluconeogenesis: Difference between revisions
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Gluconeogenesis is the production of glucose mostly from lactate, which the end product of glycolysis. Other precursors molecules such as glycerol and amino acids, repsectively derived from fat and protein catabolism. <br>Essentially, gluconeogenesis(glucose synthesis) in a sense may seems to be the reverse reaction of glcolysis(glucose breakdown). However, these two reactions are not completely irreversible, due to the "one-way" steps | Gluconeogenesis is the production of glucose mostly from lactate, which the end product of glycolysis. Other precursors molecules such as glycerol and amino acids, repsectively derived from fat and protein catabolism. | ||
The primary site of gluconeogenesis is located in the liver. It is therefore responsible for glucose homeostasis by transporting glucose throughout the systems via the bloodstream. | |||
<br>Essentially, gluconeogenesis(glucose synthesis) in a sense may seems to be the reverse reaction of glcolysis(glucose breakdown). However, these two reactions are not completely irreversible, due to the "one-way only" steps that are present in the individual biochemical processes, as well as the different catalysing enzymes involved. | |||
The three main enzymes of gluconeogenesis are pyruvate carboxylase, phosphoenol-pyruvate carboxykinase and fructose 1, 6-biphosphatase. The first step is the conversion of pyruvate into oxaloacetate. <br>These three steps are regulated by allosteric control energy-consuming(ADP for first two steps, AMP for the third step). | |||
Revision as of 10:22, 10 January 2011
Gluconeogenesis is the production of glucose mostly from lactate, which the end product of glycolysis. Other precursors molecules such as glycerol and amino acids, repsectively derived from fat and protein catabolism.
The primary site of gluconeogenesis is located in the liver. It is therefore responsible for glucose homeostasis by transporting glucose throughout the systems via the bloodstream.
Essentially, gluconeogenesis(glucose synthesis) in a sense may seems to be the reverse reaction of glcolysis(glucose breakdown). However, these two reactions are not completely irreversible, due to the "one-way only" steps that are present in the individual biochemical processes, as well as the different catalysing enzymes involved.
The three main enzymes of gluconeogenesis are pyruvate carboxylase, phosphoenol-pyruvate carboxykinase and fructose 1, 6-biphosphatase. The first step is the conversion of pyruvate into oxaloacetate.
These three steps are regulated by allosteric control energy-consuming(ADP for first two steps, AMP for the third step).