Oxaloacetate: Difference between revisions
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Oxaloacetate is a | Oxaloacetate is a key component in the [[Citric Acid Cycle|citric acid cycle]], [[Gluconeogenesis|gluconeogenesis]] and in the biosynthesis of other biological molecules, such as asparate and other amino acids, purines and [[Pyrimidine|pyrimidines]]. | ||
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In the citric acid cycle, oxaloacetate (a 4 carbon molecule) is combined with [[Acetyl-CoA|acetyl CoA]] (a 2 carbon molecule) to generate the 6 carbon molecule citric acid. Acetyl CoA is generated from the oxidation of [[Pyruvate|pyruvate]] (which also generates C0<sub>2)</sub>, and from the oxidation of fatty acids. In the eigth and last step of the citric acid cycle, oxaloacetate is regenerated from malate by malate dehydrogenase so it can once again combine with acetyl CoA and keep the cycle going. <sup></sup> | |||
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<references />Alberts et al. ''Molecular Biology of the Cell'' (2008) 5th Ed. Garland Science. Chapter 2. | <references />Alberts et al. ''Molecular Biology of the Cell'' (2008) 5th Ed. Garland Science. Chapter 2. | ||
Revision as of 14:18, 24 November 2011
Oxaloacetate is a key component in the citric acid cycle, gluconeogenesis and in the biosynthesis of other biological molecules, such as asparate and other amino acids, purines and pyrimidines.
In the citric acid cycle, oxaloacetate (a 4 carbon molecule) is combined with acetyl CoA (a 2 carbon molecule) to generate the 6 carbon molecule citric acid. Acetyl CoA is generated from the oxidation of pyruvate (which also generates C02), and from the oxidation of fatty acids. In the eigth and last step of the citric acid cycle, oxaloacetate is regenerated from malate by malate dehydrogenase so it can once again combine with acetyl CoA and keep the cycle going.
Alberts et al. Molecular Biology of the Cell (2008) 5th Ed. Garland Science. Chapter 2.