Dosage Compensation Mechanism: Difference between revisions
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= Dosage Compensation = | = Dosage Compensation = | ||
Mechanism by which X chromosome levels are re-established to levels seen in males. Such a mechanism only exists in females therefore. Dosage compensation requires RNA polymerase, Tsix transcript and Xist transcript as well as the X chromosomes of developing embryonic cells. Note that each transcript is transcribed on one chromosome each. Xist acts as to ensure inactivation of X chromosome whereas Tsix ensures X chromosome remains active. Such activity is carried out from the [[X inactivation centre|X inactivation centre]].<references /> | Mechanism by which X chromosome levels are re-established to levels seen in males. Such a mechanism only exists in females therefore. Dosage compensation requires RNA polymerase, Tsix transcript and Xist transcript as well as the X chromosomes of developing embryonic cells. Note that each transcript is transcribed on one chromosome each. Xist acts as to ensure inactivation of X chromosome whereas Tsix ensures X chromosome remains active. Such activity is carried out from the [[X inactivation centre|X inactivation centre]].<ref>Lodish, et al. 2008. (Molecular Cell Biology) 6th edition. pg 959 Fig22-7</ref><references /> | ||
Revision as of 21:24, 26 November 2011
Dosage Compensation
Mechanism by which X chromosome levels are re-established to levels seen in males. Such a mechanism only exists in females therefore. Dosage compensation requires RNA polymerase, Tsix transcript and Xist transcript as well as the X chromosomes of developing embryonic cells. Note that each transcript is transcribed on one chromosome each. Xist acts as to ensure inactivation of X chromosome whereas Tsix ensures X chromosome remains active. Such activity is carried out from the X inactivation centre.[1]
- ↑ Lodish, et al. 2008. (Molecular Cell Biology) 6th edition. pg 959 Fig22-7