Heterotrimeric G-proteins: Difference between revisions
Jump to navigation
Jump to search
Created page with 'Heterotrimeric G-proteins are made up of three subunits: alpha, beta and gamma. In its resting state, the three subunits are associated together, and GDP is bound to the …' |
No edit summary |
||
| Line 1: | Line 1: | ||
Heterotrimeric G-proteins are made up of three subunits: alpha, beta and gamma. In its resting state, the three subunits are associated together, and [[GDP|GDP]] is bound to the alpha subunit. The alpha subunit has GTP-hydrolysis activity. | Heterotrimeric G-proteins are made up of three subunits: alpha (α), beta (β) and gamma (γ). In its resting state, the three subunits are associated together, and [[GDP|GDP]] is bound to the alpha subunit. The alpha subunit has GTP-hydrolysis activity. | ||
On activation of the receptor, the alpha unit releases [[GDP|GDP]] and binds [[GTP|GTP]], and dissociates from the other subunits. The beta and gamma subunits form a dimer. | On activation of the receptor, the alpha unit releases [[GDP|GDP]] and binds [[GTP|GTP]], and dissociates from the other subunits. The beta and gamma subunits form a dimer. | ||
Revision as of 12:55, 11 November 2010
Heterotrimeric G-proteins are made up of three subunits: alpha (α), beta (β) and gamma (γ). In its resting state, the three subunits are associated together, and GDP is bound to the alpha subunit. The alpha subunit has GTP-hydrolysis activity.
On activation of the receptor, the alpha unit releases GDP and binds GTP, and dissociates from the other subunits. The beta and gamma subunits form a dimer.