MAP Kinase Kinase Kinase: Difference between revisions
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MAP (Mitogen-activating protein) Kinase Kinase Kinase ( also called MAP3K) is a type of protein kinase that [[Phosphorylation|phosphorylates]] other proteins, which include protein kinases such as Map Kinase Kinase (MEK). There is a family consisting of different types of MAP3Ks and they all react and respond to signals differently. As this protein kinase phosphorylates a MEK, it is also known as MEKK. It aids in intracellular control and helps determine the cells responses ; cell proliferation, cell death, hormonal responses and cell differentiation. It acts as a messenger in the transduction pathway in order to deliver a message to the cell, therefore, this particular protein kinase can generate many different responses in the cell. <br> | MAP (Mitogen-activating protein) Kinase Kinase Kinase ( also called MAP3K) is a type of protein kinase that [[Phosphorylation|phosphorylates]] other proteins, which include protein kinases such as Map Kinase Kinase (MEK). There is a family consisting of different types of MAP3Ks and they all react and respond to signals differently. As this protein kinase phosphorylates a MEK, it is also known as MEKK. It aids in intracellular control and helps determine the cells responses ; cell proliferation, cell death, hormonal responses and cell differentiation. It acts as a messenger in the transduction pathway in order to deliver a message to the cell, therefore, this particular protein kinase can generate many different responses in the cell. <br> | ||
The function of MAP3K is that it phosphorylates the Serine or the Threonine residues of MEK. This can be shown through the RAS signalling pathway. RAS is a G -Protein that can be activated by [[Enzyme- | The function of MAP3K is that it phosphorylates the Serine or the Threonine residues of MEK. This can be shown through the [[RAS|RAS]] signalling pathway. RAS is a G -Protein that can be activated by [[Enzyme-coupled Receptor|enzyme-coupled receptors in]] the plasma membrane ([[Monomeric G-protein|monomeric G proteins]]) and in addition is associated with SOS (Son of sevenless). RAS binds to MAP3K in order to activate it and as a result, the MEK is able to be phosphorylated by this protein kinase. In this signalling process, the MAP3K is called RAF and without it, the cascade of protein kinase would not occur and target DNA is not expressed. <br> | ||
Revision as of 00:00, 23 November 2012
MAP (Mitogen-activating protein) Kinase Kinase Kinase ( also called MAP3K) is a type of protein kinase that phosphorylates other proteins, which include protein kinases such as Map Kinase Kinase (MEK). There is a family consisting of different types of MAP3Ks and they all react and respond to signals differently. As this protein kinase phosphorylates a MEK, it is also known as MEKK. It aids in intracellular control and helps determine the cells responses ; cell proliferation, cell death, hormonal responses and cell differentiation. It acts as a messenger in the transduction pathway in order to deliver a message to the cell, therefore, this particular protein kinase can generate many different responses in the cell.
The function of MAP3K is that it phosphorylates the Serine or the Threonine residues of MEK. This can be shown through the RAS signalling pathway. RAS is a G -Protein that can be activated by enzyme-coupled receptors in the plasma membrane (monomeric G proteins) and in addition is associated with SOS (Son of sevenless). RAS binds to MAP3K in order to activate it and as a result, the MEK is able to be phosphorylated by this protein kinase. In this signalling process, the MAP3K is called RAF and without it, the cascade of protein kinase would not occur and target DNA is not expressed.