GEF: Difference between revisions
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GEF, also known as Sos, is a protein linked with the RAS pathway. It opens up the nucleotide-binding pocket of Ras. This releases GDP and allows GTP to attach to Ras, thus activating it.<ref>Berg J, Stryer L, Tymoczko J. (2011) Biochemistry, 7th Edition. International Edition, Basingstoke: Palgrave Macmillan. Page 431.</ref> | GEF, also known as Sos, is a protein linked with the [[Ras pathway|RAS pathway]]. It opens up the nucleotide-binding pocket of [[Ras|Ras]]. This releases [[GDP|GDP]] and allows [[GTP|GTP]] to attach to Ras, thus activating it.<ref>Berg J, Stryer L, Tymoczko J. (2011) Biochemistry, 7th Edition. International Edition, Basingstoke: Palgrave Macmillan. Page 431.</ref> | ||
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Revision as of 17:05, 24 November 2012
GEF, also known as Sos, is a protein linked with the RAS pathway. It opens up the nucleotide-binding pocket of Ras. This releases GDP and allows GTP to attach to Ras, thus activating it.[1]
- ↑ Berg J, Stryer L, Tymoczko J. (2011) Biochemistry, 7th Edition. International Edition, Basingstoke: Palgrave Macmillan. Page 431.