Integral membrane proteins: Difference between revisions
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Integral membrane proteins are those which are embedded directly into the phospholipid bilayer cell membrane. Although all highly specific, they can be placed into one of three categories: | Integral membrane proteins are those which are embedded directly into the [[phospholipid bilayer|phospholipid bilayer]] cell membrane. Although all highly specific, they can be placed into one of three categories: | ||
=== 1. Cytosolic Integral Membrane Proteins === | |||
Proteins which are embedded only into the inner leaflet of the [[Phospholipid bilayer|phospholipid bilayer membrane]]. | |||
Proteins | === 2. Cell Surface Proteins === | ||
Proteins which are embedded only into the outer leaflet of the [[phospholipid bilayer|phospholipid bilayer]] membrane. | |||
Proteins | === 3. Transmembrane Proteins === | ||
Proteins which span the entire [[Phospholipid_bilayer|phospholipid bilayer]] membrane, from the cytosol to the exterior of the cell. | |||
Proteins which span the entire phospholipid bilayer membrane, from the cytosol to the exterior of the cell. | |||
All integral membrane proteins can be released from the cell membrane by the use of a detergent. | All integral membrane proteins can be released from the cell membrane by the use of a detergent. | ||
Most integral proteins are either alpha helices, which can be single or multipass, or beta sheets which form a pore like structure through the membrane as a beta barrel. | Most integral proteins are either [[Alpha_helix|alpha helices]], which can be single or multipass, or beta sheets which form a pore like structure through the membrane as a [[beta barrel|beta barrel]]. | ||
Latest revision as of 01:50, 21 October 2013
Integral membrane proteins are those which are embedded directly into the phospholipid bilayer cell membrane. Although all highly specific, they can be placed into one of three categories:
1. Cytosolic Integral Membrane Proteins
Proteins which are embedded only into the inner leaflet of the phospholipid bilayer membrane.
2. Cell Surface Proteins
Proteins which are embedded only into the outer leaflet of the phospholipid bilayer membrane.
3. Transmembrane Proteins
Proteins which span the entire phospholipid bilayer membrane, from the cytosol to the exterior of the cell.
All integral membrane proteins can be released from the cell membrane by the use of a detergent.
Most integral proteins are either alpha helices, which can be single or multipass, or beta sheets which form a pore like structure through the membrane as a beta barrel.