Ubiquinone
Ubiquinone is a quinone found in the lipid bilayer and involved in the respiratory electron transport chain as an electron carrier [1]. As an electron carrier ubiquinone donates or picks up electrons in redox reactions. Ubiquinone is a small hydrophobic molecule ubiquinone has the ability to move easily through the lipid bilayer and is not located in a fixed position.
Ubiquinone, also known as coenzyme Q, plays an important role in the electron transport chain in mitochondria[2]. Coenzyme Q transfers electrons from complex I and complex II to complex III in the electron transport chain and is synthesised in all eukaryotic cells[3] . Due to the fact that ubiquinone is essential in the production of ATP, a deficiency in the cofactor can result in multiple diseases including myopathies[4].
References
- ↑ Alberts et al (2008) Molecular Biology of the Cell, 5th edition, New York: Garland Science. Chapter 14, Page 831
- ↑ Sarah L Molyneux,1,* Joanna M Young,2 Christopher M Florkowski,1,2 Michael Lever,1 and Peter M George1. Coenzyme Q10: Is There a Clinical Role and a Case for Measurement? Clin Biochem Rev. 2008 May; 29(2): 71–82.
- ↑ Trends Biochem Sci. 2017 Oct; 42(10): 824–843. Molecular Genetics of Ubiquinone Biosynthesis in Animals. Crit Rev Biochem Mol Biol. 2013 Jan-Feb; 48(1): 69–88.
- ↑ Jonathan A. Stefely1,2,3 and David J. Pagliarini1,2,*. Biochemistry of Mitochondrial Coenzyme Q Biosynthesis. Trends Biochem Sci. 2017 Oct; 42(10): 824–843.