Guanosine triphosphate
Guanosine triphosphate (Guanosine-5'-triphosphate to be precise or also commonly abbreviated GTP for simplicity) is a high energy nucleotide (not to be confused with nucleoside). As a result of it's structure it has selective roles in the formation of RNA strands[1], functioning
as an energy carrier molecule for protein synthesis[2], a coenzyme, a predecessor to cGMP - a secondary messenger molecule[3] or as an effector molecule. The last both of which are demonstrated by G-protein modulation[4]. This list does not exhuast it's chemical interactions but is merely a demonstration of it's capabilities.
The ribose sugar is central to the three dimensional arrangement of the covalently bonded guanine and the t[[]]riphosphate, providing hydroxyl groups for condensation reactions and nucleophilic attacks[5].The guanine molecule and the triphosphate form covalent bonds at C'1 and C'5 atoms respectively. The purine is bonded as a result of a condensation reaction at it's 9'N. Since guanine is a purine base, it is classified as a purine triphosphate along with adenine triphosphate (ATP)[6]. It is formed along with ATP through inosine monophosphate modification[7]. It's structural formula (right) suggests it's chemical activity and is described further in detail below.
One Of Many In RNA
GTP; A Cousin to Universal ATP
A Source For Signalling
References:
- ↑ J Koolman and KH Roehm, Color Atlas of Biochemistry, 3rd Edition, Stuttgart, Germany. Thieme 2013.
- ↑ R K Murray, D A Bender, K M Botham, P J Kennelly, V W Rodwell and P A Weil. Harper's Illustrated Biochemistry. 28th Edition. Beijing, China. 2009.
- ↑ J Dow, G Lindsay and J Morrison, Biochemistry: Molecules, Cells and the Body. 1st Edition. Wokingham, England. Addison-Wesley. 1996.
- ↑ J Dow, G Lindsay and J Morrison, Biochemistry: Molecules, Cells and the Body. 1st Edition. Wokingham, England. Addison-Wesley. 1996.
- ↑ J Dow, G Lindsay and J Morrison, Biochemistry: Molecules, Cells and the Body. 1st Edition. Wokingham, England. Addison-Wesley. 1996.
- ↑ J Koolman and KH Roehm, Color Atlas of Biochemistry, 3rd Edition, Stuttgart, Germany. Thieme 2013.
- ↑ J Koolman and KH Roehm, Color Atlas of Biochemistry, 3rd Edition, Stuttgart, Germany. Thieme 2013.