Proteasome
As stated in the paper of Peters, et al., 1994: "Proteasomes are very large protein complexes found in some of the living organisms" [1].
Proteasomes have a key essential role in the cell by controling the protein and degrading the amino acids creating new proteins [2].
In addition, proteasome controls cell-cycle progression and apoptosis which act as crutial target in anti-cancer therapy[3].
References:
- ↑ Peters, Jan-Michael; Franke, Werner W.; Kleinschmidt, Jiirgen A. (March 1994). "Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm". The Journal of Biological Chemistry 269 (10): 7709–18. PMID 8125997
- ↑ Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J (2004). "3". Molecular cell biology (5th ed.). New York: W.H. Freeman and CO. pp. 66–72. ISBN 0-7167-4366-3.
- ↑ The proteasome: structure, function, and role in the cell. http://www.ncbi.nlm.nih.gov/pubmed/12738238. 2003 May;29 Suppl 1:3-9