Conformational change

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Conformational change a change in shape of macromolecule due to the change in external or environmental factors.

Macromolecules are flexible thus it can change its shape in response to different factors[1].

In biochemistry module, the most common example for conformational change would be G-protein and different type of enzyme.

Typical Factors that could induce conformational change: 

  • temperature
  • pH value
  • presence of inhibitor/ligand (especially in enzyme)
  • mutation 

References

  1. ↑ https://en.wikipedia.org/wiki/Conformational_change


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