Metformin

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Metformin is a drug used primarily to treat type II diabetes.

Metformin works primarily by reducing hepatic gluconeogensis, ultimately lowering blood/sugar levels and preventing hyperglycemia[1].

Metformin has also shown to inhibit the growth of pancreatic cancer by disrupting crosstalk between G protein-coupled receptors and insulin receptor signalling systems in the pancreas[2]

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  1. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann Intern Med. 2002;137(1):25–33. PMID 12093242
  2. Krisztina Kisfalvi, Guido Eibl, James Sinnett-Smith, and Enrique Rozengurt. Cancer Res August 15, 2009 69; 6539