P13K

Phosphatidylinositol 3-kinase (PI3K)

Structure: Has 2 subunits:

1. Regulatory subunit, p85 (85 KDa), contains 2 SH2 domains and 1 SH3 domain.

2. Catalytic subunit, p110 (110KDa).

In the context of the Insulin pathway the p85 binds