DNA topoisomerase

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 DNA topoisomerase plays an important role in breaking the phosphodiester bond by binding covalently onto the DNA backbone phosphate. It acts as a reversible nuclease. This whole process is a reversible one, whereby before the protein leaves, the phosphodiester bonds are re-made. There are two types of DNA topoisomerase, topoisomerase I and topoisomerase II[1].


Reference :

  1. ↑ Alberts, BA, 2008. Molecular Biology of The Cell. 5th ed. New York: Garland Science.
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