Cyclic AMP

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Cyclic AMP (cAMP) is a second messenger used in cell signalling. It is synthesised from ATP by the enzyme adenylyl cyclase.

The concentration within a cell of cyclic AMP is normally around 10-7 however an extracellular signal can raise those levels within the cell by a factor of 20 within seconds.[1] Production of cyclic AMP results in the activation of Protein kinase A, which triggers cellular responses by activating enzymes, stimulating cellular secretion or opening ion channels[2].

References

  1. Alberts et al. (2008). "Molecular Biology of the Cell" (5th edition); page 854
  2. Alberts et al. (2008). "Molecular Biology of the Cell" (5th edition); page 906