Necrosis

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Unlike apoptosis, programmed cell death, necrosis occurs when a cell dies prematurely due to trauma, infections or toxins. This causes an inflammatory response, as the cells burst and contents are relased [1].Necrosis is not reversible and when the large area of the tissue dies due to inefficent blood flow to it this results in gangrene.[2] 

References

  1. Alberts et al (2008) Molecular Biology of the Cell, 5th Edition, New York: Garland Science, chapter 18
  2. MedlinePlus (2013) Necrosis. Available at: http://www.nlm.nih.gov/medlineplus/ency/article/002266.htm (last accessed 28.11.14)