G-protein linked receptor
G-protein linked receptors, also known as G-protein Coupled receptors (GPCR), are a family of receptor signal transducers which are involved in signalling pathways within cells [1].They can be further divided into to monomeric and trimeric regarding how many components mak up the G-prootein in question. Subtypes, each with an endogenous agonist, are involved in maintaining physiological systems such as rhodopsin in rod cells required for vision [2].
Structure
The structure of these proteins comprises of seven transmembrane helices with an extracellular ligand binding domain and an intracellular G-protein binding domain [3].
References
- ↑ Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg93, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman & Hall in association with the IUBMB
- ↑ Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman & Hall in association with the IUBMB
- ↑ Cascieri.Fong.Graziano.Tota.Candelore.Strader. (1996) ‘Signaling through G-Protein-coupled Receptors’, pg94, in Heldin,C. Purton,M and International Union of Biochemistry and Molecular Biology. (ed) Signal Transduction, London: Chapman & Hall in association with the IUBMB