Guanosine triphosphate
Guanosine triphosphate (Guanosine-5'-triphosphate to be precise or also commonly abbreviated GTP for simplicity) is a high energy nucleotide (not to be confused with nucleoside). As a result of it's structure it has selective roles in the formation of RNA strands[1], functioning
as an energy carrier molecule for protein synthesis[2], a coenzyme, a predecessor to cGMP - a secondary messenger molecule[3] or as an effector molecule. The last both of which are demonstrated by G-protein modulation[4]. This list does not exhuast it's chemical interactions but is merely a demonstration of it's capabilities.
The ribose sugar is central to the three dimensional arrangement of the covalently bonded guanine and the triphosphate, providing hydroxyl groups for condensation reactions and nucleophilic attacks[5].The guanine molecule and the triphosphate form covalent bonds at C'1 and C'5 atoms respectively. The purine is bonded as a result of a condensation reaction at it's 9'N. Since guanine is a purine base, it is classified as a purine triphosphate along with adenine triphosphate (ATP)[6]. It is formed along with ATP through inosine monophosphate modification[7]. It's structural formula (right) suggests it's chemical activity and is described further in detail below.
One Of Many In RNA
GTP; A Cousin to Universal ATP
A Source For Signalling
References:
- ↑ J Koolman and KH Roehm, Color Atlas of Biochemistry, 3rd Edition, Stuttgart, Germany. Thieme 2013.
- ↑ R K Murray, D A Bender, K M Botham, P J Kennelly, V W Rodwell and P A Weil. Harper's Illustrated Biochemistry. 28th Edition. Beijing, China. 2009.
- ↑ J Dow, G Lindsay and J Morrison, Biochemistry: Molecules, Cells and the Body. 1st Edition. Wokingham, England. Addison-Wesley. 1996.
- ↑ J Dow, G Lindsay and J Morrison, Biochemistry: Molecules, Cells and the Body. 1st Edition. Wokingham, England. Addison-Wesley. 1996.
- ↑ J Dow, G Lindsay and J Morrison, Biochemistry: Molecules, Cells and the Body. 1st Edition. Wokingham, England. Addison-Wesley. 1996.
- ↑ J Koolman and KH Roehm, Color Atlas of Biochemistry, 3rd Edition, Stuttgart, Germany. Thieme 2013.
- ↑ J Koolman and KH Roehm, Color Atlas of Biochemistry, 3rd Edition, Stuttgart, Germany. Thieme 2013.