Rhodopsin

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Rhodopsin is the photoreceptor protein in rod cells of vertebrate retina [1]. It is also known as opsin 2.

Rhodopsin is a member of the GPCR family, which is coupled to the G-protein, transducin. Rhodopsin, unlike many other GPCRs is activated by a photon of light not by the binding of a ligand. Infact, the ligand (11-cis retinal) is already bound in its inactive state. The photon causes a conformational change in the GPCR which causes activation of the transducin, whose α subunit, then activates cyclic GMP phosphodiesterase [2].

References

  1. Hargrave P.A., McDowell J.H.(1992) Rhodopsin and phototransduction: a model system for G protein-linked receptors. The FASEB Journal, 6(6), 2323-2331
  2. Alberts.B, Johnson.A, Lewis.J, Raff.M, Roberts.K, Walter.P, 2008, Molecular Biology of the Cell, 5th Edition, New York, Garland Science