Pre Initiation Complex

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Pre Initiation Complex (PIC)

In eukaryotic gene expression the Pre Initiation Complex (PIC) mediates the binding between the genome's promoter and RNA polymerase. Each type of RNA polymerase has a different PIC

Subunits

The complexicity of PIC varies between the types of eukaryotic RNA polymerase. For polymerases I and III the complex consists of only a few subunits.

For polymerase II the PIC is far more complex. It consists of 6 General Transcription Factors (GTF). TFIID is the core recognition protein and binds to the TATA box


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