IgM

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IgM stands for 'Immunogobulin M'. It is an antibody that is mainly concentrated in the blood and is the first to act in the primary antibody response to a pathogen/antigen [1]. IgM binds tightly to anitgens containing multiple identical epitopes due to the presence of 10 combining sites. In proteins, avidity describes the strength of multiple bonds whereas affinity denotes the binding of a single site [2].

References

  1. Molecular Biology of the Cell, fifth edition, Alberts et al, Garland Science. pages 1553-1554
  2. Biochemistry - Berg, Stryer and Tymoczko 2011