Autosomal Dominant Disorders

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An autosomal dominant disorder is a genetic disorder which the inherited offspring of the affected individuals will show the phenotype of the disorder whether they are homozygous dominant or heterozygous. In this kind of disorder, the dominant allele carries the defect while the recessive allele is the normal allele and the dominance relationship results in the individual to show the observable defect.

The Pedigree analysis for this particular disorder shows the phenotype of the defect in each generation due to the dominance relationship with equal chances of passing the defect to both males and females offspring.

Examples of autosomal dominant disorder are Pseudoachondroplasia, Huntington disease, Polydactyly and etc.[1]

References

  1. Griffths A. J. F., Wessler S. R., Lewontin R. C., Carroll S. B. (2008) Introduction to Genetic Analysis. 9th Edition. New York: W. H. Freeman and Company
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