Chargaff's rule

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It is proven that DNA is a right-handed double helix structure by Watson and Crick. Another biochemist Erwin Chargaff observed a relationship between the molarity of the four different bases. A bracket [ ] will be used to denote the molarity of the bases. Firstly, he noticed that the concentration of adenine is always equal to thymine, [A] = [T]. Secondly, the concentration of guanine is always equal to cytosine [G]=[C]. Thirdly, the concentration of purine (A and G) are always equal to pyrimidine (T and C). Hence, [A] + [G] = [C] + [T]. These are known as Chargaff's rules[1].


  1. (1) Daniel L.Hartl, Maryellen Ruvolo. Genetics analysis of genes and genomes. Eight edition. USA. Jones and Bartlett Learning. 2012
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