Cystic fibrosis-related diabetes

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Cystic fibrosis-related diabetes (CFRD), is a possible side effect of cystic fibrosis (CF) which affects 17% of the United Kingdom's CF sufferers[1]. Thick mucus secretions (a symptom of CF) cause damage to the insulin-producing cells in the pancreas (Islets of Langerhans). Whilst CFRD shares characteristics with both type 1 and type 2 diabetes, it is treated as its own distinct class[2]. CFRD results in a drastically reduced lifespan in female CF sufferes, but not in males[3].

References

  1. Wickens-Mitchell, K., Gilchrist, F. and Lenney, W. 2012. P86 The Screening and Diagnosis of Cystic Fibrosis-Related Diabetes in the United Kingdom. Thorax, 67 (Suppl 2), pp. 101--101.
  2. Moran, A., Brunzell, C., Cohen, R., Katz, M., Marshall, B., Onady, G., Robinson, K., Sabadosa, K., Stecenko, A. and Slovis, B. (2010). Clinical Care Guidelines for Cystic Fibrosis-Related Diabetes: A position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society. Diabetes Care, 33(12), pp.2697-2708.
  3. Milla, C., Billings, J. and Moran, A. (2005). Diabetes Is Associated With Dramatically Decreased Survival in Female but Not Male Subjects With Cystic Fibrosis. Diabetes Care, 28(9), pp.2141-2144.

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