Diuretics are drugs that increase the excretion of solute and water from the body. They act by inhibiting Na+ reabsorption by the nephron and as a result, Na+ is excreted along with water. This process is known as natriuresis. By inhibiting Na+ reabsorption, the volume of the extracellular fluid compartment is decreased and tubular fluid becomes more dilute as water enters by osmosis. Because of their ability to alter extracellular fluid volume, and the relationship between extracellular fluid volume and blood pressure and volume, diuretics are used in treatment of hypertension. There are different classes of diuretics which act different sites of the nephron. They are: osmotic diuretics, carbonic anhydrase inhibitors, loop diuretics, thiazide diuretics and K+-sparing diuretics .
- ↑ Bruce M Koeppen,Bruce A Stanton,Renal Physiology,Fifth Edition(2013) :167-169