Homology

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Homology In Bioinformatics.

Homology is an important aspect in exploring Bioinformatics. Homology could be described as the most fundamental relationship between two or more entities. Homology tells us how a molecule is an homolog of another molecule. Homolog is simply a molecule or organ that has the same or similar structure and function to another molecule. Homolog is classified into two main categories, paralogs and orthologs.

Paralogs are homologs present in the same species, whilst orthologs are homologs present within different species but they may have similar or identical biochemical or physiological functions. The biochemical or physiological function of a newly synthesised protein could be easily know if the protein is an homolog of another existing protein.

Statistical analysis of sequence alignment can detect homology. Based on sequence alignment of alpha haemoglobin and myoglobin, it could be inferred that these two proteins are homologs and may have descended from a common ancestor (Jeremy et al., 2007:166)[1].

References

  1. Jeremy,M.B., John,L.T., Lubert,S. (2007) Biochemistry, 6th Ed. New York, W.H. Freeman and Company.


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