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Hypoxanthine is a purine naturally found in human body and tends to be a component of nucleic acids[1]. Hypoxanthine also can be founded as intermediates in adenine degradation. Specifically, when purine nucleoside phosphorylates reacts with inosine will create hypoxanthine. Afterward, hypoxanthine is converted into xanthine by xanthine oxidase[2]. Another way that hypoxanthine can formed is from deamination of adenine. This particular formation of hypoxanthine can result in a mutation in transcription or DNA replication because hypoxanthine has a similar structure to guanine; thus, hypoxanthine will be read as guanine and will form a hydrogen bond with cytosine[3].


  1. Jarvis H, Marc O. Biochemical Methods of Estimating the Time Since Death. Human Body Decomposition. 2016;3;53-90.
  2. Paul GW, Christopher JM, Vivienne RW, David RB, Mone Z. Free radical pathways in the inflammatory response. New Comprehensive Biochemistry. 1994;28;361-383.
  3. Berg JM, Tymoczko JL, Stryer L. Mutations Involve Changes in the Base Sequence of DNA. Biochemistry. 2002;527.6
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