Long term potentiation

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Long term potentiation (LTP) is thought to result in learning and memory. Single action potentials fired in presynaptic cells aren't thought to have much of a long term affect. However, repeated firing of action potentials is believed to increase the quality and quantity of synaptic transmission. This process was initially noticed in the hippocampus, where some synapses display functional alterations with repeated use. The effect can vary in the length of time it stays around for, it can be from hours to weeks [1].


  1. Alberts, Johnson, Lewis, Raff, Roberts, Walter (2008) Molecular Biology of the Cell, 5Th Edition, New York: Garland Science, Taylor and Francis group Page 691

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