Na+-K+ channel pumps
How An Na+/K+ Pump Works
The Na+/K+ pump has two different conformational states known as E1 and E2. 3 Na+ bind to the intracllular binding site, the phosphorlyation of the pump using the ATP causes the conformational change within the pump. The pump is now in conformational state E2, the 3 Na+ are released outside of the cell. The binding of the 2 K+ to the extracellular surface results in the dephosphorylation of the pump returning the configuration back to E1, once in the E1 conformation the 2K+ are released into the cell.
- ↑ Siegel GJ, Agranoff BW, Albers RW, et al. Basic Neurochemistry: Molecular, Cellular and Medical Aspects-Chapter 5-Membrane Transtport.6th edition. Philadelphia: Lippincott-Raven; 1999.
- ↑ Alberts B., Johnson A., Lewis J., Raff. M, Roberts K. Walter P. Molecular Biology of The Cell- Chapter10-Membrane Structure. 5th Ed, New York: Garland Science. Taylor &amp;amp;amp; Francis Group LLC. 2008
- ↑ Darnell J.E., Lodish H., Berk. A, Zipursky L., Matsudaira P., Baltimore D. Cell Biology. 4th edition. 4th Ed, London: W.H.Freeman &amp;amp;amp;amp; Co Ltd. 1999