Noncovalent bonds

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 Chemical bonds are essentials in the interaction between atoms and molecules. These bonds can be either covalent or noncovalent. Noncovalent bonds are weaker than the covalent ones and they are fundamental for several biochemical procesess like maintaining the three dimensional structures of proteins and nucleic acids[1]. Even though they are weak bonds, multiple noncovalent bonds act together to produce transient stable structure and specific associations between different parts of large molecule or among various macromolecules. For instance they are essentials in the formation of a double helix.

There are four major types of noncovlent bonds: electrostatic interactions,hydrogen bonds, van der Waals interaction, and hydrophobic interactions[2]


  1. Berg, J., Tymoczko, J. and Stryer, L. (2011). Biochemistry. 1st ed. New York: W. H. Freeman: 6-7
  2. Wilson, J. and Hunt, T. (2002). Molecular biology of the cell. 1st ed. New York, London: Garland.

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