From The School of Biomedical Sciences Wiki
Nuclear receptors are intracellular receptors, found in either in the cytosol or in the nucleus, bind ligands such as steroid hormones, thyroid hormones and fat-soluble vitamin A and vitamin D .
Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence-specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate transcription and gene expression.
- ↑ Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.
- ↑ Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp;amp; Francis. 2008