Protein kinase C

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Protein kinase C (PKC) is a molecule that can phosphorylate certain targeted proteins by adding one or more phosphate groups, this will either activate or deactivate the targeted protein. PKC is a serine/threonine protein kinase which is called protein kinase C because it is calcium (Ca2+) dependant [1]. PKC is involved in many second messenger cell signalling pathways and during these pathways it moves from the cytosol to the the cytosolic side the the cell surface membrane in order to phosphorylate the appropriate protein in the pathway [2]. When the phospholipid PIP2 is split into IP3 and DAG the latter helps activate Protein Kinase C and IP3 stimulates more Ca2+ release.


  1. Alberts (2008) Molecular biology of the cell, 5th edition, pages; 626, 895 ,911. Garland Science, Madison Avenue,New York.
  2. Alberts et al. (2008) Molecular biology of the cell, 5th edition,pages; 626,895,911. Garland Science, Madison Avenue, New York.
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