S. pombe

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Schizosaccharomyces pombe or S. pombe is a species of yeast often used as a model organism in biological research. S. pombe is also known as 'fission yeast'[1] as it divides by splitting rather than budding like the other major yeast model, Saccharomyces cerevisiae. The genome of S. pombe was sequenced in 2001 making it the 6th eukaryotic model organism to have it's genome sequenced[2]. Since then, scientists have discovered over fifty genes in S. pombe which are directly associated with human diseases such as diabetes, hereditary deafness and cystic fibrosis[3], making the organism a useful tool in developing treatments[4][5][6]. The indirect immunofluorescence microscopy of S. pombe has been highly important in the understanding of mitosis being that it is a fission yeast as elongation of the spindle during mitosis revealed the appearance of astral microtubules originating from the cytoplasmic spindle pole body[7].

References:

  1. S.Pombe Initiative, National Institute of Health, Susan L Forsburg, available at: http://nih.gov/science/models/Schizosaccharomyces/index.html, accessed 26/11/14
  2. The model unicellular eukaryote, Schizosaccharomyces pombe, US National Library of Medicine, available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139019/, accessed 26/11/14
  3. Schizosaccharomyces pombe: Second yeast genome sequenced, Genome News Network, Birgit Reinert, available at: http://www.genomenewsnetwork.org/articles/03_02/s_pombe.shtml, accessed 26/11/14
  4. S.Pombe Initiative, National Institute of Health, Susan L Forsburg,available at: http://nih.gov/science/models/Schizosaccharomyces/index.html, accessed 26/11/14
  5. The model unicellular eukaryote, Schizosaccharomyces pombe, US National Library of Medicine, available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139019/, accessed 26/11/14
  6. Schizosaccharomyces pombe: Second yeast genome sequenced, Genome News Network, Birgit Reinert, available at: http://www.genomenewsnetwork.org/articles/03_02/s_pombe.shtml, accessed 26/11/14
  7. The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe, I.M. Hagan, J.S. Hyams Journal of Cell Science 1988 89: 343-357 available at: http://jcs.biologists.org/content/89/3/343.short accessed 4/12/17.
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