Spindles

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Spindles are the structures that begin to form in prophase of mitosis. They extend from the centrioles at the poles of the dividing cell and fix onto the centromeres on the chromosomes, which have aligned on the metaphase plate, during metaphase [1].

Spindles are made from microtubulin which is added onto the gorowing end of the spindle fibres as they form. The function of the spindles is to provide axis between the poles of the cell on which chromosomes can move along during anaphase of mitosis in preparation for cytokinesis [2].

References

  1. Cooper GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. Microtubules. Available from: http://www.ncbi.nlm.nih.gov/books/NBK9932/
  2. Sadava, D. et al. Life: The Science of Biology, 8th ed. (Sunderland, MA: Sinauer Associates and W. H. Freeman and Company), 189
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