Stop codon

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STOP codons are produced by a sequence of three bases and there are three different kind UAA, UGA and UAG. RF1 and RF2 (bacterial release factors) can identify these particular stop codons at the A-site of a ribosome and they have the ability to break the bond at the peptidyl-tRNA site, causing the dissociation of the translated polypeptide. The difference between the two release factors is that RF1 recognises the stop codons UAA and UAG, and RF2 recognises UAA and UGA. These are usually found on the end of the open reading frame and prevents further transcription from occuring during DNA replication[1].


  1. Sund J, Andér M, Aqvist J, 2010, Principles of stop-codon reading on the ribosome, 465 (7300), 947-50
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