Troponin C (along with Troponin I and Troponin T) is a regulatory proteins residing in the grooves of the thin filament. Troponin C plays an important role in muscle contraction by presenting itself as the binding site to which Calcium ions flowing in from the sarcoplasmic reticulum can bind. This binding causes the Troponin molecules to "shape-shift" and changed their shape to free up the actin-myosin binding site the troponin and tropomyosin was previously hiding, to allow access for the myosin head to bind.
- ↑ Boron, Walter F., Boulpaep, Emile L., Medical Physiology 2nd edition. Saunders 2008. Pages 238-240. Accessed November 23 2011.
- ↑ Freudenrich, Craig, HowStuffWorks "How Muscles Work". 2011. HowStuffWorks "How Muscles Work". [ONLINE] Available at: http://science.howstuffworks.com/environmental/life/human-biology/muscle.htm. [Accessed 23 November 2011].